Designing of Oral Sustained Release Bioadhesive Drug Delivery System

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2018, 2018

3659712914 / 9783659712913

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This item is printed on demand - Print on Demand Titel. Neuware -The objective of the present study was to develop 'once daily' sustained-release bioadhesive tablet of Zaltoprofen (ZLT) and Lornoxicam (LXM) which will deliver the drug it in small doses over an extended period and localizing it in the intestine by bioadhesion. ZLT is a new non-steroidal anti-inflammatory drug which has anti-inflammatory, analgesic and antipyretic effect and frequently used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. ZLT has short biological half-life (4.96 - 7.48h) and blood drug level decrease in short time so that patients need frequent administration (t.i.d). The sustained-release polymers, hydroxypropyl methylcellulose (HPMC) of different viscosities and xanthan gum evaluated in different proportions as a major matrix material. Drug-polymer compatibility studies by FTIR and DSC gave confirmation about their purity and showed no interaction physically between drug and selected polymers. ZLT matrix tablets were prepared by wet granulation. The effect of polymer concentration on the drug release profile and in-vitro bioadhesion of the matrix tablets was studied.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 336 pp. Englisch.…

Seller Inventory # 9783659712913

Title
Designing of Oral Sustained Release Bioadhesive Drug Delivery System
Author
Kiran Aher
Publisher
LAP LAMBERT Academic Publishing Sep 2018
Publication year
2018
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659712914
ISBN 13
9783659712913
Item weight
518 grams
Dimensions
220x150x21 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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