Design and evaluation of solid dispersion of water insoluble drug

Language: English

Published by LAP LAMBERT Academic Publishing Dez 2015, 2015

3659816450 / 9783659816451

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This item is printed on demand - Print on Demand Titel. Neuware -Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. Solid dispersions demonstrated a higher dissolution rate than physical mixtures and pure drug. The solvent evaporation method of preparing solid dispersions was found to be satisfactory as it produced good product with high drug content. Out of the 18 formulations prepared, formulation A5 showed marked increase in the solubilityVDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.…

Seller Inventory # 9783659816451

Title
Design and evaluation of solid dispersion of water insoluble drug
Author
Vachaspati Dubey
Publisher
LAP LAMBERT Academic Publishing Dez 2015
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659816450
ISBN 13
9783659816451
Item weight
167 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

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