Design and Synthesis of Gd(3+) Based MRI Contrast Agents

Language: English

Published by LAP LAMBERT Academic Publishing, 2014

3659632821 / 9783659632822

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine.MRI contrast agents are used to increase the sensitivity of this technique.1,4,7,10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln3+ ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method.Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this method cancer tissues are selectively destroyed without injuring the surrounding healthy cells. However, for the successful use of this method, the selection of an appropriate photosensitizer is important. Hence, it diagnosis-treat union of MRI and PDT will be significantly promoted if a new family of bi-functional agents is found, which would combine the effects of a contrast agent in MRI and of a photosensitizer in PDT. It will bring great improvement to the cancer diagnosis and treatment.…

Seller Inventory # 9783659632822

Title
Design and Synthesis of Gd(3+) Based MRI Contrast Agents
Author
Haroon Ur Rashid
Publisher
LAP LAMBERT Academic Publishing
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659632821
ISBN 13
9783659632822
Item weight
221 grams
Dimensions
220x150x9 mm

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