Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Band 8)

Carlson, Rolf

ISBN 10: 044489201X / ISBN 13: 9780444892010

Published by Elsevier Science Ltd, 1992

About this Item

Zustand: Sehr gut | Seiten: 552 | Produktart: Sonstiges.

Seller Inventory # 42482292/202

Bibliographic Details

• Title: Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Band 8)
• Publisher: Elsevier Science Ltd
• Publication Date: 1992
• Language: English
• ISBN 10: 044489201X
• ISBN 13: 9780444892010
• Binding: Hardcover
• Edition: 3rd Edition
• Condition: Sehr gut
• Seller catalogs:
  • Sonstiges

About this title

Synopsis

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

Review

"This is a welcome re-issue for a modern classic of the organic chemistry literature. The author presents a revised and enlarged edition, incorporating some fresh material, updated references, and novel strategies. I would urge all organic chemists to read this book and become acquainted with these valuable tools. Provides methods by which good chemists will be able to do even better chemistry."

Derek Robinson, ORGANIC PROCESS RESEARCH AND DEVELOPMENT, 2005