The Design and Analysis of Sequential Clinical Trials

John Whitehead

ISBN 10: 0471975508 / ISBN 13: 9780471975502

Published by John Wiley and Sons Ltd, 1997

About this Item

In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results. Num Pages: 328 pages, Illustrations. BIC Classification: MBGR; MBNS. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 241 x 163 x 23. Weight in Grams: 618. . 1997. Revised, 2nd Edition. Hardcover. . . . . Books ship from the US and Ireland.

Seller Inventory # V9780471975502

Bibliographic Details

• Title: The Design and Analysis of Sequential Clinical Trials
• Publisher: John Wiley and Sons Ltd
• Publication Date: 1997
• Language: English
• ISBN 10: 0471975508
• ISBN 13: 9780471975502
• Binding: Hardcover
• Edition: 2nd Edition
• Condition: New

About this title

Synopsis

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

About the Author

John Whitehead is the author of The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition, published by Wiley.