The Design and Analysis of Sequential Clinical Trials (Hardcover)

John Whitehead

ISBN 10: 0471975508 / ISBN 13: 9780471975502

Published by John Wiley & Sons Inc, New York, 1997

About this Item

Hardcover. This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials. Sequential Clinical Trials are those where data from patients treated at the beginning of a trial can be analysed while the trial is on-gong and subsequent patients are recruited. This analysis provides stopping rule whereby the number of patients involved can be limited without affecting the results. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Seller Inventory # 9780471975502

Bibliographic Details

• Title: The Design and Analysis of Sequential Clinical Trials (Hardcover)
• Publisher: John Wiley & Sons Inc, New York
• Publication Date: 1997
• Language: English
• ISBN 10: 0471975508
• ISBN 13: 9780471975502
• Binding: Hardcover
• Edition: 2nd Edition
• Condition: new

About this title

Synopsis

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

About the Author

John Whitehead is the author of The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition, published by Wiley.