Data Mining in Structural Biology

Language: English

Published by Springer, J.B. Metzler Apr 2014, 2014

3662046474 / 9783662046470

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This item is printed on demand - Print on Demand Titel. Neuware -Structural biology is becoming a routine technique for structure de termination in pharmaceutical industries. The advances in molecular biology, crystal handling and data collection techniques, tunable syn chrotron radiation sources, and high-performance computing have all contributed to developments such as the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperature. The number of protein structures deposited in the Protein Databank has increased tremendously over the last 3-4 years. Since 1997, more than 1,500 structures have been deposited each year, and during the first 7 months of this year, 1,500 protein structures were already deposited. The numerous initiatives in the field of 'structural genomics' distributed all over the world have led to the development of techniques for high-throughput structure determina tion, thereby contributing to the increase in the determination of three dimensional protein structures. This structural information is being ex plored in various ways in the drug discovery process. It is not only used in structure-based drug design of new low-molecular-weight li gands, but also in the early stages of target validation and assessment. With the number of protein sequences without significant homology to well-known proteins increasing, the technique of structure-sequence compatibility (threading) is increasingly used to assign a function to a given protein fold.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 224 pp. Englisch.

Seller Inventory # 9783662046470

Title
Data Mining in Structural Biology
Author
I. Schlichting
Publisher
Springer, J.B. Metzler Apr 2014
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3662046474
ISBN 13
9783662046470
Item weight
296 grams
Dimensions
210x148x13 mm

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