DNA binding properties and anticancer studies of hydrazone complexes : Spectral characterization,DNA binding properties and anticancer studies of hydrazone complexes with Ni, Co and Cu metals

Language: English

Published by LAP LAMBERT Academic Publishing, 2021

620472648X / 9786204726489

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - In this current research, we focus on the synthesis of Ni, Co and Cu complexed hydrazones related to 2-acetylpyridine acetoylhydrazone (APAH), 2-acetylpyridine benzoylhydrazone (APBH), 2-benzoylpyridine acetoylhydrazone (BPAH), 2-benzoylpyridine benzoylhydrazone (BPBH) due to their biological activities. In order to study their anti- cancer activities, the hydrazones were substituted by different heterocyclic groups and their molecular docking was also tested using AutoDock 4.2.2 software. Its Infra-Red, proton, carbon-13 nuclear magnetic resonance and mass spectral data identified the structures of all manufactured compounds. The few hydrazones against tested complexes were tested for anti-cancer and their molecular docking simulations were also studied. To some degree, the result was lined up by the change in its structures, with few of the complexes exhibiting improved functions than the reference drug used. Silico molecular docking simulations have been achieved to position 2-acetylpyridine acetoylhydrazone (APAH), 2-acetylpyridine benzoylhydrazone (APBH), 2-benzoylpyridine acetoylhydrazone (BPAH), 2-benzoyl pyridine benzoylhydrazone (BPBH) molecules.…

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Title
DNA binding properties and anticancer studies of hydrazone complexes : Spectral characterization,DNA binding properties and anticancer studies of hydrazone complexes with Ni, Co and Cu metals
Author
Mohammed Fadhil Eesee
Publisher
LAP LAMBERT Academic Publishing
Publication year
2021
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
620472648X
ISBN 13
9786204726489
Item weight
209 grams
Dimensions
220x150x8 mm

AHA-BUCH GmbH

Einbeck, Germany

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