DNA Relaxases, the Key Enzymes of Bacterial Conjugation : TraA and Its N-terminal Relaxase Domain of theGram-positive Plasmid pIP501 Show Specific oriTBinding and Behave as Dimers in Solution
Language: English
Published by VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K., 2008
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 48.11
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Since Sir Alexander Flemming in the early 20thcentury discovered penicillin, the war betweenbacteria and humans began. The antibiotic saved thelives of millions of people during the World War IIbut bacteria evolved a mechanism to inactivate theantibiotics. New antibiotic substances have beendiscovered or synthesized but bacteria always seem tofind a way to survive.The most frequent way how bacteria acquire antibioticresistance genes is conjugation. It is a specificunidirectional process of horizontal gene transferduring which plasmid DNA is transferred from donor torecipient cell. Relaxases are essential forconjugative plasmid transfer; they start the processby nicking plasmid DNA by trans-esterification.TraA is the DNA relaxase encoded by thebroad-host-range Gram-positive plasmid pIP501.Small-angle X-ray scattering and chemicalcross-linking proved that TraAN246 and TraA formdimers in solution. Both proteins revealed oriTpIP501cleavage activity on supercoiled plasmid DNA in vitro.…
Seller Inventory # 9783639069501
- Title
- DNA Relaxases, the Key Enzymes of Bacterial Conjugation : TraA and Its N-terminal Relaxase Domain of theGram-positive Plasmid pIP501 Show Specific oriTBinding and Behave as Dimers in Solution
- Author
- Jolanta Kopec
- Publisher
- VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K.
- Publication year
- 2008
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3639069501
- ISBN 13
- 9783639069501
- Item weight
- 171 grams
- Dimensions
- 220x150x6 mm
"Synopsis" may belong to another edition of this title.
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