DNA Recognition with Dimeric Calixarenes : Towards Sequence-Selective DNA Recognition with Designed Major Groove Binders

Language: English

Published by Scholars' Press, 2015

3639761324 / 9783639761320

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nach der Bestellung gedruckt Neuware - Printed after ordering - This work was performed during the period from August 2007 to April 2011 at the Department of Organic Chemistry, University of Duisburg-Essen, under the supervision of Prof. Dr. Thomas Schrader. Firstly, we synthezed a new class of calixarene dimers and elucidated their binding mechanism towards various nucleic acids. The results of multiple established DNA binding assays provided experimental evidence for noncovalent major groove recognition. Secondly, we replaced the simple alkyl bridge between both calixarenes by a triimidazole bridge. The triimidazole bridge was able to recognize the base sequence, and we found that this dimer showed the strongest affinity for a predicted DNA sequence. We believed that our work paved the way to sequence-selective DNA recognition inside the major groove.

Seller Inventory # 9783639761320

Title
DNA Recognition with Dimeric Calixarenes : Towards Sequence-Selective DNA Recognition with Designed Major Groove Binders
Author
Wenbin Hu
Publisher
Scholars' Press
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3639761324
ISBN 13
9783639761320
Item weight
453 grams
Dimensions
220x150x19 mm

AHA-BUCH GmbH

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