Cystogenesis

Language: English

Published by Springer, 2016

981102040X / 9789811020407

Series: Book 261 of 544 - Advances in Experimental Medicine and Biology

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.…

Seller Inventory # 9789811020407

Title
Cystogenesis
Author
Jong Hoon Park
Publisher
Springer
Publication year
2016
Condition
Neu
Binding
Buch
Language
English
ISBN 10
981102040X
ISBN 13
9789811020407
Item weight
350 grams
Dimensions
241x160x13 mm
Series
Book 261 of 544: Advances in Experimental Medicine and Biology

AHA-BUCH GmbH

Einbeck, Germany

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AbeBooks seller since August 14, 2006

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