Controlled Permeable Polymersomes Decorated with Functional-Antennae for Biomedical Applications

Language: English

Published by Tudpress Verlag Der Wissenschaften Gmbh, Tudpress Verlag Der Wissenschaften Gmbh Nov 2014, 2014

3944331877 / 9783944331874

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This item is printed on demand - Print on Demand Titel. Neuware -In the context of diligent efforts to improve the tumor targeting efficiency of drug carriers, a shape-persistent polymersome which possess a pH-tunable membrane as well as folate targeting antennae is reported. The membrane of such polymersomes behaves as gate which undergoes ¿on¿ and ¿off¿ switches in response to pH stimuli. Thus, polymersomes can effectively prohibit the premature release of chemotherapeutic agents such as doxorubicin in physiological conditions, but promote drug release once they are triggered in the acidified endosomal compartment. Importantly, the folate moieties are installed on the surface of polymersomes as protruding antennae by doping the polymersomes with folate-terminated block copolymers designed to have longer PEG segments. Thereby, the folate moieties are freed from concealment and steric effects exerted by the dense PEG corona. The cellular uptake of the FAantennae polymersomes by tumor cells is signifi cantly enhanced facilitated by the freely accessible folate antennae; however, the normal cells record a low level of cellular uptake due to the stealth property of the PEG corona. Overall, the excellent biocompatibility, controlled permeability, targeted internalization, as well as selective cytotoxicity of such polymersomes set up the basis for properly smart carrier for targeted drug delivery.TUDpress, Hüblerstraße 26, 01309 Dresden 172 pp. Englisch.…

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Bibliographic details

Title
Controlled Permeable Polymersomes Decorated with Functional-Antennae for Biomedical Applications
Author
Mohamed A. Yassin
Publisher
Tudpress Verlag Der Wissenschaften Gmbh, Tudpress Verlag Der Wissenschaften Gmbh Nov 2014
Publication year
2014
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3944331877
ISBN 13
9783944331874
Item weight
534 grams
Dimensions
247x180x17 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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