Controlled Permeable Polymersomes Decorated with Functional-Antennae for Biomedical Applications
Language: English
Published by Tudpress Verlag Der Wissenschaften Gmbh, 2014
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 51.24
Quantity: 1 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - In the context of diligent efforts to improve the tumor targeting efficiency of drug carriers, a shape-persistent polymersome which possess a pH-tunable membrane as well as folate targeting antennae is reported. The membrane of such polymersomes behaves as gate which undergoes 'on' and 'off' switches in response to pH stimuli. Thus, polymersomes can effectively prohibit the premature release of chemotherapeutic agents such as doxorubicin in physiological conditions, but promote drug release once they are triggered in the acidified endosomal compartment. Importantly, the folate moieties are installed on the surface of polymersomes as protruding antennae by doping the polymersomes with folate-terminated block copolymers designed to have longer PEG segments. Thereby, the folate moieties are freed from concealment and steric effects exerted by the dense PEG corona. The cellular uptake of the FAantennae polymersomes by tumor cells is signifi cantly enhanced facilitated by the freely accessible folate antennae; however, the normal cells record a low level of cellular uptake due to the stealth property of the PEG corona. Overall, the excellent biocompatibility, controlled permeability, targeted internalization, as well as selective cytotoxicity of such polymersomes set up the basis for properly smart carrier for targeted drug delivery.…
Seller Inventory # 9783944331874
Bibliographic details
- Title
- Controlled Permeable Polymersomes Decorated with Functional-Antennae for Biomedical Applications
- Author
- Mohamed A. Yassin
- Publisher
- Tudpress Verlag Der Wissenschaften Gmbh
- Publication year
- 2014
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 3944331877
- ISBN 13
- 9783944331874
- Item weight
- 474 grams
- Dimensions
- 247x180x17 mm
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