Control of Breathing During Exercise (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)

Ward, Susan A.

ISBN 10: 1615043721 / ISBN 13: 9781615043729

Published by Morgan & Claypool Life Sciences, 2014

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Seller Inventory # U9781615043729

Bibliographic Details

• Title: Control of Breathing During Exercise (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)
• Publisher: Morgan & Claypool Life Sciences
• Publication Date: 2014
• Language: English
• ISBN 10: 1615043721
• ISBN 13: 9781615043729
• Binding: Soft cover
• Edition: 1755865508.
• Condition: Very Good
• Dust Jacket Condition: 47226568
• Signed: 8/22/2025 12:25:08 PM
• Seller catalogs:
  • 1
  • U
  • 9781615043729

About this title

Synopsis

The control of breathing during exercise remains the source of considerable debate. Classical schemes of the exercise hyperpnea have incorporated elements of proportional feed-back from chemoreceptor sites (carotid body and brainstem) and feed-forward neurogenic (central command and muscle reflex) control. However, the precise details of the control process are still not fully resolved, reflecting in part technical and interpretational limitations inherent in isolating putative control mechanisms in the intact exercising human and also the challenges presented by the ventilatory and gas-exchange complexities encountered at work rates which engender a metabolic (lactic) acidosis. Although some combination of neurogenic, chemoreflex, and circulatory-coupled processes are likely to contribute to the control, intriguingly, the overall system appears to evidence considerable redundancy. This, coupled with the lack of appreciable steady-state error signals in the mean levels of arterial PCO2, PO2, and pH over a wide range of work rates, has motivated the formulation of innovative control models that reflect not only spatial interactions but also temporal interactions (i.e., short-term and longer-term ‘memory’). The challenge remains to discriminate between robust control schemes that (a) integrate such processes within plausible physiological equivalents, and (b) account for both the dynamic and steady-state system response over the entire range of exercise intensities. Table of Contents: Introduction / Ventilatory Requirements / Ventilatory Responses / Ventilatory Control / Conclusions / References

About the Author

Emeritus Professor, Faculty of Biological Science, University of Leeds and Human Bio-Energetics Research Centre, Crickhowell, Powys, United Kingdom