Excerpt from The Conduction of the Nervous Impulse

In one sense it has been obvious from the first that the student Of the central nervous system has common interest with the investigator of peripheral nerve. One of the chief concerns of the latter is to discover the physico-chemical change which is the basis of conduction; and, as Sherrington has said, the intimate nature of conduction is a problem coextensive with the existence of nerve cells, and enters into every question regarding the specific reactions of the nervous system. But when the student of conduction in peripheral nerve leaves aside the physico-chemical theory of the nervous impulse and attempts merely to investigate in detail the phenomena of conduction, then it has seemed to many that his work becomes academic, and loses touch with the great human interests of the nervous system. Conduction in peripheral nerves is a rigid affair, seeming to lack just those features, Inhibition, Summation, Rhythm, After-discharge, which give to central conduction its ﬂexibility and its means of adaptation to specific ends.

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