Combining Human Genetics and Causal Inference to Understand Human Disease and Development
Language: English
Published by Cold Spring Harbor Laboratory Press Jan 2022, 2022
- Hardcover
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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Neuware - In human genetics, causal inference methods leverage large omics data sets and phenotypic information to decipher various cause-and-effect relationships in human health and disease (e.g., smoking and lung cancer). The focus of such work is typically on modifiable variables (e.g., behavior or environmental exposure) that impact disease onset, progression, and outcome. A better understanding of these variables can lead to interventions and therapeutics that have a desirable impact on public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines advances in causal inference approaches in human genetics and how they are being used to enhance our understanding of human development and disease. The contributors discuss family-based study designs for causal inference, including twin designs, adoption designs, and in vitro fertilization designs, that separate inherited factors from perinatal environmental exposures. They also review various types of Mendelian randomization--a population-based approach that is growing in utility and popularity--as well as their integration with family-based designs. The use of these approaches to investigate causal mechanisms in specific scenarios (e.g., maternal smoking during pregnancy and ADHD in offspring) is also covered. This volume is therefore an essential read for geneticists, epidemiologists, and all biomedical scientists and public health professionals dedicated to using genetic information to improve human health.…
Seller Inventory # 9781621823810
- Title
- Combining Human Genetics and Causal Inference to Understand Human Disease and Development
- Author
- Rebecca Richmond
- Publisher
- Cold Spring Harbor Laboratory Press Jan 2022
- Publication year
- 2022
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 1621823814
- ISBN 13
- 9781621823810
- Item weight
- 748 grams
- Dimensions
- 257x178x20 mm
- Series
- Book 34 of 42: Perspectives CSHL
Topics covered in this essential volume include:
- The Meaning of "Cause" in Genetics
- Twins and Causal Inference: Leveraging Nature's Experiment
- Mendelian Randomization: Concepts and Scope
- Integrating Family-Based and Mendelian Randomization Designs
- Computational Tools for Causal Inference in Genetics
- Using Mendelian Randomization to Improve the Design of Randomized Trials
"Synopsis" may belong to another edition of this title.
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