Clinical Nephrotoxins. This item is unavailable.Clinical Nephrotoxins

This is a comprehensive handbook on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The book consists of a general part dealing with themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. The second part includes the specific drugs, for instance the anti-infectious agents, anti-inflammatory drugs, cardiovascular drugs, anti-cancer drugs and so forth. The last part deals with the prevention consisting of urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this second and completely revised edition, several new topics were added, information regarding the paediatric age group was expanded and up-to-date references provided, while remaining true to the concept of a multinational author book.

"The first section, on general matters, contains the best short account of "renal handling of drugs and xenobiotics" that I have seen. One chapter is a thorough account of urinary biomarkers that would be worthwhile reading for anyone contemplating a clinical study and wanting information on what might be measured to indicate nephrotoxicity. In summary, the books contains some splendid articles on nephrotoxicity and nephrotoxins, from a scientific perspective [...] this could become a comprehensive and standard text."
(John Firth in The Lancet, January 2004)