Clinical Integration: Medicine helps medical students and junior doctors link basic medical science with clinical context and build an appreciation of how pathophysiology manifests as recognisable clues.

The book shows readers the logical connections between patient history, examination findings, investigation results, management rationale and their underlying mechanisms. Readers learn to understand the “why and how” behind the diagnosis, investigation and management of common clinical problems.
The book uses a system-based approach to cover 100 clinical cases, from aortic dissection to urinary tract infections, via dementia and pneumothorax. Every case uses a consistent format to:

highlight the key elements of the history, examination, investigation and treatment phases of medical practice
provide rapid access to important facts
explore the links between pathophysiology and clinical clues that underpin common medical conditions

Chapter 1 Cardiology
Cases 1–10: Aortic dissection; Aortic stenosis; Atrial fibrillation; Heart failure with reduced ejection fraction; Mitral regurgitation; Mobitz 2 second-degree heart block; Pericarditis; ST elevation myocardial infarction; Stable angina; Ventricular tachycardia

Chapter 2 Endocrinology
Cases 11–20: Addison’s disease; Conn’s disease; Cushing’s syndrome; Hyperthyroidism; Hypothyroidism; Osteoporosis; Paget’s disease; Primary hyperparathyroidism; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Chapter 3 Gastroenterology and hepatology
Cases 21–30: Acute pancreatitis; Cholelithiasis; Coeliac disease; Decompensated liver cirrhosis; GORD and oesophagitis; Hepatitis A, B and C; Inflammatory bowel disease; Non-alcoholic fatty liver disease; Oesophageal achalasia; Peptic ulcer disease

Chapter 4 Haematology
Cases 31–40: Acute myeloid leukaemia; Chronic lymphocytic leukaemia and non-Hodgkin lymphoma; Chronic myeloid leukaemia; Haemolytic anaemia; Haemophilia; Hodgkin lymphoma; Idiopathic thrombocytopenic purpura; Iron-deficiency anaemia; Multiple myeloma; Venous thromboembolism

Chapter 5 Infectious diseases
Cases 41–50: Cellulitis; Gastroenteritis; HIV/AIDS; Infective endocarditis; Malaria; Meningoencephalitis; Osteomyelitis; Pneumonia; Septic arthritis; Urinary tract infections

Chapter 6 Neurology
Cases 51–60: Acute inflammatory demyelinating polyradiculoneuropathy; Acute intracerebral haemorrhage; Dementia; Motor neurone disease; Multiple sclerosis; Muscular dystrophy; Myasthenia gravis; Parkinson’s disease; Spinal cord injury; Stroke

Chapter 7 Oncology
Cases 61–70: Breast carcinoma; Colorectal carcinoma; Head and neck carcinoma; Hepatocellular carcinoma; Melanoma; Pancreatic carcinoma; Prostate carcinoma; Pulmonary carcinoma; Renal cell carcinoma; Testicular carcinoma

Chapter 8 Renal
Cases 71–80: Acute kidney injury; Chronic kidney disease; Dialysis-related hypotension; Hyperkalaemia; Hypokalaemia; Hyponatraemia; Lupus nephritis; Nephrolithiasis; Nephrotic syndrome; Renal transplant rejection

Chapter 9 Respiratory
Cases 81–90: Acute respiratory distress syndrome; Asbestosis; Asthma; Chronic obstructive pulmonary disease; Cystic fibrosis; Idiopathic pulmonary hypertension; Interstitial lung disease; Lung transplantation; Pleural effusion; Pneumothorax

Chapter 10 Rheumatology
Cases 91–100: ANCA-associated vasculitis; Ankylosing spondylitis; Giant cell arteritis; Gout; Non-specific low back pain; Osteoarthritis; Polymyositis, Rheumatoid arthritis; Scleroderma; SLE

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