Chromosomal Instability in Cancer Cells
Language: English
Published by Springer International Publishing, 2015
- Hardcover
- New
Condition: New
£ 40.67
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Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Reviews up-to-date knowledge of chromosomal instability in cancerExamines strategies to harness this information for the better treatment of cancer patientsWritten by acknowledged experts in the fieldThis issue of Recent Resul.
Seller Inventory # 31550032
- Title
- Chromosomal Instability in Cancer Cells
- Author
- Ghadimi, B. Michael|Ried, Thomas
- Publisher
- Springer International Publishing
- Publication year
- 2015
- Condition
- New
- Binding
- Gebunden
- Language
- English
- ISBN 10
- 3319202901
- ISBN 13
- 9783319202907
- Dimensions
- 1.8 x 24.2 x 16.2
- Series
- Book 141 of 157: Recent Results in Cancer Research
- Seller catalogs
- Mathematik/Naturwissenschaften/Technik/Medizin
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
"Synopsis" may belong to another edition of this title.
From the Back Cover
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
"About the title" may belong to another edition of this title.
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