Chitosan-based heart valve with improved mechanical properties

Language: English

Published by LAP LAMBERT Academic Publishing Mär 2012, 2012

3848436736 / 9783848436736

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This item is printed on demand - Print on Demand Titel. Neuware -Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability.However, its use in load-bearing applications is limited due to moderate to low mechanical properties.In this work,we investigated the effectiveness of a fiber reinforcement method for enhancing the mechanical properties of chitosan scaffolds.The results showed that incorporating fibers improved scaffold strength and stiffness in proportion to the fiber/scaffold mass ratio.A fiber-reinforced heart valve leaflet scaffold achieved strength values comparable to the radial values of human pulmonary and aortic valves.Various chemical and physical treatments were studied to improve the mechanical properties of chitosan fibers.With combination of chemical and physical treatments, fiber stiffness improved 40fold compared to unmodified fibers.Utility of isolated ovine bone marrow-derived MSCs was evaluated for cardiovascular tissue engineering applications. The effect of various glycosaminoglycans (GAGs) on MSCs morphology and proliferation was evaluated. Lastly, studies showed that MSCs proliferation improved in proportion to fiber stiffness.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 140 pp. Englisch.…

Seller Inventory # 9783848436736

Title
Chitosan-based heart valve with improved mechanical properties
Author
Mohammad Albanna
Publisher
LAP LAMBERT Academic Publishing Mär 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3848436736
ISBN 13
9783848436736
Item weight
227 grams
Dimensions
220x150x9 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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