Title: Chemical Induction of Cancer: Modulation and Combination Effects an Inventory of the Many Factors which Influence Carcinogenesis
Publisher: Birkh�user
Publication Date: 1996
Language: English
ISBN 10: 0817637664
ISBN 13: 9780817637668
Binding: Hardcover
Condition: New

About this title

Synopsis

In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.

Synopsis

This text provides a perspective on the complex aetiology of cancer. The topics are grouped into two parts: Part 1 covers cross-reactions between carcinogens and modification of chemical carcinogenesis by noncarcinogenic agents; Part 2 examines exogenous factors and endogenous biological parameters that modulate chemical carcinogenesis. The chapters in Part 1 discuss: the combination effects between carcinogens (synergism and antagonism); modification of chemical carcinogenesis by inhibitors, promoters and carcinogens; intercellular communication as an interpretive paradigm for the modification of carcinogenesis; mathematical modelling in the evaluation of carcinogen interactions; and a computerized database search and logic system for the assessment of relative carcinogenic potency of chemical mixtures. Chapters in Part 2 discuss: other exogenous as well as endogenous factors that modulate chemical carcinogenesis; immunotoxicity of carcinogens, diet (caloric intake, protein/amino acids, vitamins, minerals and fibre); age of the organism; hormones and modification of the endocrine status; genetic susceptibility; radiations; viruses; stress; and electromagnetic fields.

Because of the dominant role that the oncogene concept, signal transduction and tumour-suppressor genes play in the understanding of the mechanism of carcinogenesis, special emphasis is given to the chapter discussing viral-chemical interactions and the molecular biology of viral tumourigenesis.

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