Central Nervous System Diseases and Inflammation

Thomas E. Lane

ISBN 10: 144194480X / ISBN 13: 9781441944801

Published by Springer US, Springer US, 2010

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Up until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood-brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS.

Seller Inventory # 9781441944801

Bibliographic Details

• Title: Central Nervous System Diseases and Inflammation
• Publisher: Springer US, Springer US
• Publication Date: 2010
• Language: English
• ISBN 10: 144194480X
• ISBN 13: 9781441944801
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 19D millimeters 235 millimeters width by 155 millimeters height by 19 millimeters depth
• Weight: 505 grams

About this title

Synopsis

Edited and authored by top names in the field, this book provides a succinct and well organized reference on inflammatory central nervous system disease. It focuses on current areas of investigation within the fields of neuroimmunology, virology, pharmacology, and disease. Sections of the text focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. Although other books treat this topic, this book’s unique organization provides a quick, concise overview of inflammatory CNS disease. The book is intended for researchers, clinicians, and students in immunology, neuroimmunology, virology, microbiology, pharmacology, and medicine.

From the Back Cover

This volume serves as a succinct and well-organized reference volume focused on inflammatory CNS disease to a wide audience. The text is comprised of four sections revolving around current areas of interest in the fields of neuroimmunology, virology, pharmacology and disease. Sections of this text focus on a specific category of diseases as well as the pharmacological, virological, and immunological effects of and on the disease.

Although many have covered this topic, few have provided a volume as concise and efficient. Each disease is broken down on a variety of scientific levels without getting into the history of the disease. This approach provides a succinct overview of a specific subject encompassing interrelated topics pertaining to neurology, immunology and disease. The information provided in Central Nervous System Diseases and Inflammation will be useful for researchers, clinicians, as well as a valuable resource for students interested in the fascinating arena of neuroinflammation.