Cefixime Trihydrate Sustained Release Matrix Tablet : To study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet
Language: English
Published by Scholars' Press, 2013
- Softcover
- Used
Condition: Used - Fine
£ 44.53
Quantity: 1 available
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Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | The present work aims to study effect of diff. viscosity grade of HPMC on cefixime trihydrate sustained release matrix tablet with a view to prolong drug release in vivo & reduce frequency of dosing. Cefixime Trihydrate is an orally active third generation cephalosporin and active against Gram+ve as well as Gram -ve bacteria. It has plasma half-life of 3-4 hrs. The Sustained release matrix tablets were prepared by wet granulation method using diff. grade of HPMC, Lactose, MCC & PVP K-30. The granules were subjected to pre-compression & post-compression parameters and they were in the acceptable limits. The in vitro drug release from HPMC matrices in accordance with its diff. proportion and viscosity grade was HPMC K-100M > K-15M > K-4M with ratio of (1, 1.5, 2) individually in formulation F1-F9 and (0.5, 0.75, 1) ratio in F10-F12. Drug-excipient interaction was performed by DSC & FTIR; results were shown that there was no interaction. After 3 months stability study at 400C/75% RH, formulations found to be stable. So as the viscosity and proportion of HPMC increases release rate from sustained release cefixime trihydrate matrix tablet decreases.…
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- Title
- Cefixime Trihydrate Sustained Release Matrix Tablet : To study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet
- Author
- Patel, Parth
- Publisher
- Scholars' Press
- Publication year
- 2013
- Condition
- Sehr gut
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 3639515536
- ISBN 13
- 9783639515534
- Seller catalogs
- Bücher
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