Caveolins and Caveolae : Roles in Signaling and Disease Mechanisms

Language: English

Published by Springer New York, 2012

1461412218 / 9781461412212

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.…

Seller Inventory # 9781461412212

Title
Caveolins and Caveolae : Roles in Signaling and Disease Mechanisms
Author
Michael P Lisanti
Publisher
Springer New York
Publication year
2012
Condition
Neu
Binding
Buch
Language
English
ISBN 10
1461412218
ISBN 13
9781461412212
Item weight
542 grams
Dimensions
269x187x20 mm

AHA-BUCH GmbH

Einbeck, Germany

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