Cationic Polymers based Non-viral Gene Carriers: Pharmaceutical Applications of Nano-vectors in Transfection Technology

Pathak, Atul, C. Gupta, Kailash

ISBN 10: 3843376190 / ISBN 13: 9783843376198

Published by LAP LAMBERT Academic Publishing, 2011

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Bibliographic Details

• Title: Cationic Polymers based Non-viral Gene Carriers: Pharmaceutical Applications of Nano-vectors in Transfection Technology
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2011
• Language: English
• ISBN 10: 3843376190
• ISBN 13: 9783843376198
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Nucleic acids-based next generation biopharmaceuticals (i.e., oligonucleotides, siRNA) are potential therapeutic agents have ability to cope with various incurable diseases. However, several biological barriers present a challenge for efficient gene delivery. Inception of nanotechnology now offer numerous non-viral vectors that have been fabricated and found capable of transmitting the biopharmaceuticals into the cell and even into specific subcellular compartments like mitochondria. This book illustrates novel chemically modified polyallylamine and polyethylenimine based nano- vectors for enhanced gene delivery. Modification of these polymers using imidazolyl and polysaccharides such as hyaluronic acid, chondroitin sulfate and heparin not only improve cytotoxicity index but also provides site-specificity for cell-type specific gene delivery. Incorporation of targeting moiety minimizes the chance of potential adverse effects and also reduces the amount the amount of dose required to achieve desired therapeutic effects. Recent developments in formulation of efficient drug carriers showed potential to develop gene therapy again diseases like cancer.

About the Author

Dr. Atul Pathak is a Research Fellow at Immune Disease Institute, Program and Cellular and Molecular Medicine at Children Hospital, Harvard Medical School, Boston, USA. He earned his Ph.D. in Pharmaceutical Science. Dr. Kailash C. Gupta is a director of Indian Institute of Toxicology Research, India.