CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Language: English
Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Okt 2010, 2010
Series: Book 9 of 322 - Current Topics in Microbiology and Immunology
- Softcover
- New
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000
AbeBooks seller since January 23, 2017
Condition: New
£ 189.38
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Add to basketItem description from seller
This item is printed on demand - Print on Demand Titel. Neuware -yetwehopethatitwillofferinspirationandorientationtothescientistwho wouldliketoenterthis eld. To date, many different cells have been described that can suppress + + other cells of the immune system: CD4 CD25 regulatory T cells (Treg), + CD4 CD25 regulatory T cells, T regulatory 1 cells (Tr1), T-helper 3 cells + (Th3),CD8 CD28 Tcells,NKTcells,aswellastolerogenicdendriticcells. Suppressive CD4 T cells fall at least into two categories. So called natural VI Preface + + CD4 CD25 Tregformpartoftheintra-thymicallyselectedTcellrepertoire andapparentlyconstituteadistinctlineage. Incontrast,¿adaptive¿regulatory Tcellsareinstructedintheperipherytobecomesuppressivecells,theyform + + amoreheterogeneousgroupincludingCD4 CD25 Treg,Tr1,andTh3cells. As natural Treg are so far the best characterized entity, the rst three contributionsofthisvolume(C. Cozzoetal. ,C. -S. Hsiehetal. ,andL.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch.…
Seller Inventory # 9783642063763
- Title
- CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
- Author
- Elisabeth Suri-Payer
- Publisher
- Springer Berlin Heidelberg, Springer Berlin Heidelberg Okt 2010
- Publication year
- 2010
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3642063764
- ISBN 13
- 9783642063763
- Item weight
- 585 grams
- Dimensions
- 235x155x22 mm
- Series
- Book 9 of 322: Current Topics in Microbiology and Immunology
"Synopsis" may belong to another edition of this title.
From the Back Cover
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.
The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
"About the title" may belong to another edition of this title.
buchversandmimpf2000
Emtmannsberg, BAYE, Germany
AbeBooks seller since January 23, 2017
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