Brain Lipids in Synaptic Function and Neurological Disease : Clues to Innovative Therapeutic Strategies for Brain Disorders
Language: English
Published by Elsevier Science, 2015
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.…
Seller Inventory # 9780128001110
- Title
- Brain Lipids in Synaptic Function and Neurological Disease : Clues to Innovative Therapeutic Strategies for Brain Disorders
- Author
- Jacques Fantini
- Publisher
- Elsevier Science
- Publication year
- 2015
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 0128001119
- ISBN 13
- 9780128001110
- Item weight
- 981 grams
- Dimensions
- 243x200x25 mm
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.
- Written to provide a "hands-on" approach for readers
- Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings
- Step-by-step guide to memorize and draw lipid structures
- Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
"Synopsis" may belong to another edition of this title.
About the Author
Nouara Yahi was born in France in 1964. She has accumulated 25 years of fundamental research and teaching experience in virology and molecular biology areas. She has been a pioneer in the analysis of resistance mutations in patients with HIV infections, and has published several important articles in this field. She is currently professor of biochemistry at Aix-Marseille University and leader of the research group ‘Molecular Interactions in Model and Biological Membrane Systems’. This group is internationally recognized for studies of lipid-lipid and lipid-protein interactions pertaining to virus fusion, amyloid aggregation, oligomerization and pore formation. Together with her teammate Jacques Fantini, Nouara Yahi has discovered the universal sphingolipid-binding domain (SBD) in proteins with no sequence homology but sharing common structural features mediating sphingolipid recognition. The SBD is present in a broad range of infectious and amyloid proteins, revealing common mechanisms of pathogenesis in viral and bacterial brain infections, and in neurodegenerative diseases. Nouara Yahi is the author/co-author of 90 articles (PubMed), with 4400 citations and a H-index of 40. She has also published 5 patent applications.
"About the title" may belong to another edition of this title.
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