Boolean Networks as Predictive Models of Emergent Biological Behaviors

Jordan C. Rozum, Colin Campbell, Eli Newby, Fatemeh Sadat Fatemi Nasrollahi, Réka Albert

ISBN 10: 100929296X / ISBN 13: 9781009292962

Published by Cambridge University Press, GB, 2024

Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions - from molecules in gene regulatory networks to species in ecological networks - and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization. Seller Inventory # LU-9781009292962

Synopsis:

This Element shows Boolean models of biological systems predicting these systems' responses to perturbations and control interventions.

Bibliographic Details

Title: Boolean Networks as Predictive Models of ...
Publisher: Cambridge University Press, GB
Publication Date: 2024
Binding: Paperback
Condition: New