Biomimetic Function of Iron Sulfur Clusters with Alternative Ligands. Model Studies Using Synthetic Analogues

Language: English

Published by Cuvillier, Cuvillier Dez 2017, 2017

3736996721 / 9783736996724

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Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000

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This item is printed on demand - Print on Demand Titel. Neuware -Iron sulfur clusters are essential cofactors involved in electron transfer, sensing, and catalysis in all three kingdoms of life. While most iron sulfur clusters are ligated by cysteine thiolates, a number of clusters featuring so called alternative ligands such as histidine have been recognized in recent years. This work uses synthetic [2Fe-2S] analogues to explore the role alternative ligands play in determining the reactivity of iron sulfur clusters. Isomerization in a homoleptically coordinated cluster utilizing a mixed nitrogen- and sulfur-donating ligand is investigated as a model for ligand rearrangement processes during iron sulfur cluster biogenesis. Furthermore, a high fidelity model system for the asymmetrically ligated [2Fe-2S] cluster of mitoNEET proteins is developed and characterized in detail. This cluster and its homoleptic analogue are studied as reagents in proton coupled electron transfer processes, highlighting the role asymmetry and reorganization energy play in tuning this reactivity. The effects of the ligation pattern on entropic contributions during reduction are probed by temperature dependent electrochemical measurements. Finally, synthetic [2Fe-2S] clusters are investigated with respect to their reactivity with organic radicals, mimicking the unique reactivity of biotin synthase.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 198 pp. Englisch. …

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Bibliographic details

Title
Biomimetic Function of Iron Sulfur Clusters with Alternative Ligands. Model Studies Using Synthetic Analogues
Author
Marie Bergner
Publisher
Cuvillier, Cuvillier Dez 2017
Publication year
2017
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3736996721
ISBN 13
9783736996724
Item weight
264 grams
Dimensions
210x148x11 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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