Biomedical Image Synthesis and Simulation: Methods and Applications presents the basic concepts and applications in image-based simulation and synthesis used in medical and biomedical imaging. The first part of the book introduces and describes the simulation and synthesis methods that were developed and successfully used within the last twenty years, from parametric to deep generative models. The second part gives examples of successful applications of these methods. Both parts together form a book that gives the reader insight into the technical background of image synthesis and how it is used, in the particular disciplines of medical and biomedical imaging. The book ends with several perspectives on the best practices to adopt when validating image synthesis approaches, the crucial role that uncertainty quantification plays in medical image synthesis, and research directions that should be worth exploring in the future.

Gives state-of-the-art methods in (bio)medical image synthesis
Explains the principles (background) of image synthesis methods
Presents the main applications of biomedical image synthesis methods

About the Authors

Ninon Burgos is a CNRS researcher at the Paris Brain Institute, in the ARAMIS Lab, and a fellow of PR[AI]RIE, the Paris Artificial Intelligence Research Institute, France. She completed her PhD at University College London, UK, with a thesis on image synthesis for the attenuation correction and analysis of hybrid positron emission tomography/magnetic resonance imaging data. In 2019, she received the ERCIM Cor Baayen Young Researcher Award. Her research focuses on the processing and analysis of medical images, the use of images to guide the diagnosis of neurological diseases, and the application of these methods to the clinic.

David Svoboda is an associate professor at the Department of visual computing of the Faculty of Informatics, Masaryk University, Brno, Czech Republic. He completed his PhD in computer science with a thesis on segmentation of volumetric histopathological images. He spent a half-year research visit at Manchester Metropolitan University, Manchester, UK, in the signal processing group, where he focused on the problems on edge detection using the statistics-based filtering. Since 2006, he has been with the Centre for Biomedical Image Analysis at Masaryk University. His current research fields include the manipulation of huge image data and the generation of synthetic microscopy image data, both static and time-lapse sequences.

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