Biomedical Engineering Program between Rutgers University and the University of Medicine and Dentistry of New Jersey entitled "Biopolymers" and "Patho� biology" during the past 15 years. It is our hope that this book will provide the reader with all the infor� mation necessary to understand the complexity of the biological reactions that are set into motion by implantation of a material or a device. We hope that this book will provide a framework for thinking about implant interactions with bio� logical systems. Although the field of studying pathobiological responses to im� plants is still in its infancy, we are now more aware of acute and chronic con� ditions that generate inflammatory responses as a result of wear debris, activation of complement, and acute hypersensitivity. As we learn more concerning these responses, it is hoped that our ability to design implants will also improve. We encourage readers to send to us any suggestions of additional topics that they would like to see covered in our book. Frederick H. Silver David L.

Synopsis

This text for students and researchers, takes an interdisciplinary approach to describing the chemistry and physics of materials, their biocompatibility, and the consequences of implantation of devices made of these materials into the human body. The reader is introduced to the principles of polymer science and the study of metals, ceramics and composites, and also to the basic biology required to understand the nature of the host-transplant interface. Topics covered in this book include the macromolecular components of cells and tissues, self-assembly processes, biological cascade systems, microscopic structure of cells and tissues, immunology, transplantation biology, and the pathobiology of wound healing. Topics covered in the materials science chapters include the structures and properties of polymers, metals, ceramics and composites, and the processes for forming materials as well as the pathobiology of devices. The final two chapters deal with tissue engineering and the relations between the biology of cells and tissue transplantation, and the engineering of tissue replacements using passaged cells.

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