Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers
Language: English
Published by Academic Press, 2019
- Softcover
- Used
Seller: suspiratio - online bücherstube lic.phil h.b., Basel, Switzerlandsuspiratio - online bücherstube lic.phil h.b.
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- Title
- Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers
- Author
- Karsdal, Morten
- Publisher
- Academic Press
- Publication year
- 2019
- Condition
- Sehr gut
- Binding
- Softcover
- Language
- English
- ISBN 10
- 0128170689
- ISBN 13
- 9780128170687
- Edition
- 2. Auflage.
There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, 2nd Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease.
"Synopsis" may belong to another edition of this title.
About the Author
Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.
"About the title" may belong to another edition of this title.
suspiratio - online bücherstube lic.phil h.b.
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