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Bacterial Adhesins (Current Topics in Microbiology and Immunology)


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ISBN 10: 3642747051 / ISBN 13: 9783642747052
Published by Springer, 2011
Condition: Good Soft cover
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Title: Bacterial Adhesins (Current Topics in ...

Publisher: Springer

Publication Date: 2011

Binding: Paperback

Book Condition: Good

About this title


The great majority of bacterial infections are initiated by the adhesion of pathogenic bacteria to cells and mucosal surfaces of the host. The sequela of adhesion may range from the action of toxins outside target cells to their penetration into or through tissue. Besides the consequences of bacterial adhesion related in infection, the result may be colonization of mucosal surfaces with normally harmless bacteria, which in stress situations may become virulent, a phenomenon known as nosocomial infections. With very few exceptions, adhesion is carbohydrate speci- fic. It is mediated by bacterial recognition proteins that are, according to the phenomenon studied, termed adhesins or hem agglutinins; the term "lectin" is sometimes also used. The chemical nature of the ad he sins and their organization on the bacterial surface have been studied intensively in many laboratories. The application of genetic and biochemical techniques has led to substantial progress in the molecular characterization of adhesins in recent years. We now know that adhesins may occur as structural subunits of fimbriae and that they may form fimbriae which can be considered as mono- or multifunctional linear adhesin polymers. Other adhesins do not form recognizable structures and are tenta- tively called nonfimbrial. Adhesins may even be components of bacterial cell walls. Adhesin-receptor specificities have been unravelled. The study of the distribution of receptors in tissue has created implications about the possible susceptibility to infections.

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This volume is devoted to the characteristics and function of bacterial adhesins (recognition proteins) which mediate bacterial attachment to host tissue at an initial stage in infection. Ten articles written by experts in the field look into the genetics, biochemistry, surface organization and receptor specificity of adhesins. Medical aspects such as receptor distribution in tissue and its relevance to susceptibility to infection, the role of adhesins in infection and inflammation and the elaboration of adhesin based vaccines are included. Since E. coli is one of the best studied microorganisms, the main focus is on E. coli adhesins, references being made to other related systems. In addition to presenting current data, general principles behind the facts are emphasized. This book not only addresses experts in microbiology, microbial biochemistry and infection research, but also those generally interested in the subject.

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