Attempts to Understand Metastasis Formation III

Language: English

Published by Springer, Springer Dez 2011, 2011

3642800734 / 9783642800733

Series: Book 118 of 322 - Current Topics in Microbiology and Immunology

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This item is printed on demand - Print on Demand Titel. Neuware -In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas tasis research and to attempt to further understand the biol ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno logy compile the most recent developments on these meta stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 284 pp. Englisch.

Seller Inventory # 9783642800733

Title
Attempts to Understand Metastasis Formation III
Author
Ursula Günthert
Publisher
Springer, Springer Dez 2011
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642800734
ISBN 13
9783642800733
Item weight
435 grams
Dimensions
235x155x16 mm
Series
Book 118 of 322: Current Topics in Microbiology and Immunology

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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