Antisnake Venom Property of Plant Andrographis Paniculata: Anti-snake venom property of A. paniculata and its comparison with polyvalent ASV

Salwe, Kartik J., Premendran, S. John, Pathak, Swanand S.

ISBN 10: 3659177385 / ISBN 13: 9783659177385

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Antisnake Venom Property of Plant Andrographis Paniculata: Anti-snake venom property of A. paniculata and its comparison with polyvalent ASV
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659177385
• ISBN 13: 9783659177385
• Binding: paperback
• Condition: Like New
• Book Type: book

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Synopsis

The study was undertaken to investigate the neutralizing effect of the alcoholic extract of Andrographis paniculata against the Indian Cobra (Naja naja) and Russell’s viper venom. The lethal dose 99 (LD99) value of snake venom was calculated and then the venom-neutralizing ability of the plant extract at doses of 1 and 2 g/kg was determined using in vitro and in vivo methods. The alleviation in the mean survival time of the animals was used to infer the antivenin property of the drug after challenging it with the LD99 value of snake venom. The ethanolic extract of plant A. paniculata significantly increases the mean survival time and the protection fold but could not protect animals from death when used alone. Polyvalent anti-snake venin (ASV) was found to be more effective than the plant extract. When the plant extract was given along with polyvalent ASV, it potentiated its effect. The observation demonstrates that the ethanolic extract of A. paniculata has an anti-venom activity against the Indian Cobra and the Russell’s viper venom which is comparable with polyvalent ASV.

About the Author

Dr. Kartik Janardan Salwe is currently Assistant professor in Mahatma Gandhi Medical College and Research Institute Pillaiyarkuppam Puducherry. He is reputed teacher with 5 years of teaching experiance. He has published more than 10 scientific papers in both national and international journals.