Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles

Language: English

Published by Cuvillier Jan 2012, 2012

395404000X / 9783954040001

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This item is printed on demand - Print on Demand Titel. Neuware -The oral bioavailability of a drug substance is strongly related to its aqueous solubility.Only complete dissolution during the GI-passage can maintain an optimalbioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunnerequation into a slow dissolution rate, sometimes too slow for complete dissolution inthe GI tract. The dissolution rate increases with decreasing particle size and thereforeincreasing surface area of the drug particles. In consequence, micronization of thedrug is applied to increase oral bioavailability, but often meets with modest success.Recently developed techniques were applied to decrease the particle size into thenanometer range. For some substances, pharmacokinetic parameters could beinfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant andfenofibrate. 200 pp. Englisch.

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Bibliographic details

Title
Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Author
Daniel Jünemann
Publisher
Cuvillier Jan 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
395404000X
ISBN 13
9783954040001
Item weight
266 grams
Dimensions
210x148x12 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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AbeBooks seller since January 23, 2017

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Impressum Thorsten Retsch Buchversand Mimpf2000 Oberölschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir führen gebrauchte Bücher aus allen Sparten der Literatur

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