Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Language: English
Published by Cuvillier Jan 2012, 2012
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 26.98
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -The oral bioavailability of a drug substance is strongly related to its aqueous solubility.Only complete dissolution during the GI-passage can maintain an optimalbioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunnerequation into a slow dissolution rate, sometimes too slow for complete dissolution inthe GI tract. The dissolution rate increases with decreasing particle size and thereforeincreasing surface area of the drug particles. In consequence, micronization of thedrug is applied to increase oral bioavailability, but often meets with modest success.Recently developed techniques were applied to decrease the particle size into thenanometer range. For some substances, pharmacokinetic parameters could beinfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant andfenofibrate. 200 pp. Englisch.
Seller Inventory # 9783954040001
Bibliographic details
- Title
- Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
- Author
- Daniel Jünemann
- Publisher
- Cuvillier Jan 2012
- Publication year
- 2012
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 395404000X
- ISBN 13
- 9783954040001
- Item weight
- 266 grams
- Dimensions
- 210x148x12 mm
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
| Item | 5 to 15 business days | 5 to 15 business days |
|---|---|---|
| First item | £ 19.47 | £ 19.47 |
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Seller's business information
BuchWeltWeit Ludwig Meier e.K.
Germany
Terms of sale
BuchWeltWeit Inh. Ludwig Meier e.K.
Inhaber: Ludwig Meier
De-Gasperi-Str. 8
51469 Bergisch Gladbach
Deutschland
Tel.: +49(0)22028659300
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E-Mail: info@buchweltweit.de
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Registernummer: HRA 28253
Umsatzsteuer-Identifikationsnummer: DE815259907
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