Amoxycillin Trihydrate Floating-Bioadhesive Drug Delivery System
Language: English
Published by LAP LAMBERT Academic Publishing Nov 2016, 2016
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 31.67
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -The content of the present investigation was to formulate and evaluate floating-bioadhesive tablets of amoxicillin trihydrate (ATFBT) to provide local action in the treatment of Helicobacter Pylori (H. Pylori) by prolonging the gastric residence time. The FBT were prepared by direct compression method using combination of hydroxy propyl methyl cellulose (HPMC K4M) and chitosan (CH), carbopol (CP974P) and polymethacrylic acid (PMA) as release retardants and bioadhesive polymers, and sodium bicarbonate (NaHCO3) as a gas-former. The prepared tablets were evaluated for their physical characters such as drug content, in vitro buoyancy, swelling index, in vitro drug release and stability studies. Further, the bioadhesive strength (BS) was determined using porcine gastric mucosa. DSC studies indicate the compatibility of the drug and excipients used in the formulation. The optimized formulation (F7) showed floating lag time of 32 ± 2.7 sec, total floating time more than 12 h, BS of 1.86±0.14 N, swelling index of more than 3.5 and was found to be physically stable when stored at 40oC/75% RH for 3 months. 84 pp. Englisch.…
Seller Inventory # 9783330002258
- Title
- Amoxycillin Trihydrate Floating-Bioadhesive Drug Delivery System
- Author
- Ramesh Bomma
- Publisher
- LAP LAMBERT Academic Publishing Nov 2016
- Publication year
- 2016
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3330002255
- ISBN 13
- 9783330002258
- Item weight
- 143 grams
- Dimensions
- 220x150x6 mm
"Synopsis" may belong to another edition of this title.
About the Author
"About the title" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
| Item | 5 to 15 business days | 5 to 15 business days |
|---|---|---|
| First item | £ 19.70 | £ 19.70 |
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BuchWeltWeit Ludwig Meier e.K.
Germany
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BuchWeltWeit Inh. Ludwig Meier e.K.
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