Alpha-Keto Acid Dehydrogenase Complexes: Organization, Regulation, and Biomedical Ramifications (Annals of the New York Academy of Sciences)

Roche, Thomas E.; Patel, Mulchand S. [Editor]

ISBN 10: 0897665392 / ISBN 13: 9780897665391

Published by New York Academy of Sciences, 1990

About this Item

Softcover. Good binding and cover. Shelfwear. Stamps to page ends and fep. Clean, unmarked pages. Ships daily.

Seller Inventory # 1611290005

Bibliographic Details

• Title: Alpha-Keto Acid Dehydrogenase Complexes: Organization, Regulation, and Biomedical Ramifications (Annals of the New York Academy of Sciences)
• Publisher: New York Academy of Sciences
• Publication Date: 1990
• Language: English
• ISBN 10: 0897665392
• ISBN 13: 9780897665391
• Binding: Hardcover
• Condition: Very Good
• Weight: 28 ounces
• Seller catalogs:
  • Science, Math, Space and Engineering

About this title

Synopsis

Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.