Ago-driven Non-coding Rnas: Codes to Decode the Therapeutics of Diseases
Language: English
Published by Academic Pr, 2019
- Softcover
- New
Seller: Revaluation Books, Exeter, United KingdomRevaluation Books
AbeBooks seller since January 6, 2003
Condition: New
£ 257.17
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Add to basketItem description from seller
363 pages. 9.00x7.25x0.75 inches. In Stock.
Seller Inventory # __0128156694
- Title
- Ago-driven Non-coding Rnas: Codes to Decode the Therapeutics of Diseases
- Author
- Mallick, Bibekanand (Editor)
- Publisher
- Academic Pr
- Publication year
- 2019
- Condition
- Brand New
- Binding
- Paperback
- Language
- English
- ISBN 10
- 0128156694
- ISBN 13
- 9780128156698
- Item weight
- 0.95 kilograms
The 'RNA world' hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health.
This book captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therap
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About the Author
Dr. Bibekanand Mallick is an Associate Professor and Head of the Department of Life Science at the National Institute of Technology Rourkela, where he has been serving since 2009. He has had an excellent academic career at reputed alma maters, including the Indian Institute of Technology Kharagpur, the Indian Association for the Cultivation of Science, Kolkata, and the Wadsworth Center, New York State Department of Health, United States. He leads the ‘RNAi and Functional Genomics’ Laboratory at the National Institute of Technology Rourkela and conducts a wide range of research on various aspects of non-coding RNAs, including miRNAs, piRNAs, and lncRNAs, as well as their crosstalk (ceRNAs) and their regulatory impacts on diseases such as cancer and neurodegenerative disorders. He has published several research papers in highly reputed international journals and books with respected publishers such as Oxford and Springer-Verlag during his academic career. Recently, he was honored as a Member of the National Academy of Sciences, India (MNASc) in recognition of his significant contributions to understanding the “dark matter of the RNA world.
"About the title" may belong to another edition of this title.
Revaluation Books
Exeter, United Kingdom
AbeBooks seller since January 6, 2003
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Edward Bowditch Ltd
Exstowe, Exton
Exeter, United Kingdom EX3 0PP
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