Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection, and Biological Consequences

Ali Esat Karakaya Miral Dizdaroglu

ISBN 10: 0306460424 / ISBN 13: 9780306460425

Published by Kluwer Academic/Plenum Publishers, 1999

Ancien livre de bibliothèque. Edition 1999. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Edition 1999. Ammareal gives back up to 15% of this item's net price to charity organizations. Seller Inventory # E-984-397

Synopsis:

In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.

Synopsis: Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurrence of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms.In recent years, the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistance of human cells to DNA-damaging agents.

This volume covers the most recent developments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology.

Bibliographic Details

Title: Advances in DNA Damage and Repair: Oxygen ...
Publisher: Kluwer Academic/Plenum Publishers
Publication Date: 1999
Binding: Hardcover
Condition: Très bon