Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome (Hardcover)

Language: English

Published by Royal Society of Chemistry, Cambridge, 2021

1839161639 / 9781839161636

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Hardcover. The efficient analysis of polar and charged metabolites in biological samples remains a huge challenge in the field of metabolomics. Over the past years, novel mass spectrometry-based analytical tools have been developed to enable the sensitive and efficient profiling of polar ionogenic metabolites in various biological samples. This book gives the reader a comprehensive overview of these recent technological developments. Topics covered include the use of chemical labelling strategies for allowing the analysis of polar metabolites using reversed-phase liquid chromatographymass spectrometry (RPLC-MS) and the latest methodological developments in RPLC-MS, hydrophilic interaction liquid chromatography (HILIC)-MS and ion-pair LC-MS approaches. Attention is also paid to developments in nano-LC-MS and capillary electrophoresismass spectrometry methods specifically for profiling polar metabolites in small volume biological samples. The utility of ion-mobility MS and NMR spectroscopy will also be outlined. Sample preparation is the key part in the analytical workflow employed for metabolomics. Therefore, ample emphasis will be given on recent solid-phase extraction and solid-phase micro-extraction methods. Finally, analytical techniques for chiral metabolic profiling will also be considered. Discussing the state-of-the-art of the proposed topics in one single book for probing the polar metabolome, using relevant examples, is unique and needed in the metabolomics field. This book has relevance and appeal to an international audience of analytical and biomedical researchers in industry and academia. Discussing the state-of-the-art of the proposed topics in one single book for probing the polar metabolome, using relevant examples, is unique and needed in the metabolomics field. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Title
Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome (Hardcover)
Author
Rawi Ramautar
Publisher
Royal Society of Chemistry, Cambridge
Publication year
2021
Condition
new
Binding
Hardcover
Language
English
ISBN 10
1839161639
ISBN 13
9781839161636

Grand Eagle Retail

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