APPLICATION OF SOLID-STATE KINETICS TO DESOLVATION REACTIONS
Ammar Khawam
ISBN 10: 3639091140 ISBN 13: 9783639091144
Published by VDM Verlag Dr. Müller, 2013
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APPLICATION OF SOLID-STATE KINETICS TO DESOLVATION REACTIONS | Ammar Khawam | Taschenbuch | Kartoniert / Broschiert | Englisch | 2013 | VDM Verlag Dr. Müller | EAN 9783639091144 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu. Seller Inventory # 101701608
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The book presents an overview of the solid-state kinetic literature including methodologies used, mathematical derivations and pharmaceutical applications. The book investigates the relationship between calculation methods and artifactual results observed in solid-state kinetics. A new approach is proposed for evaluating solid-state kinetic data, this approach combines modelistic and model-free methods in a complimentary manner to achieve consistent kinetic results. Experimental data focused on studying the solid-state stability of several structurally related solvates of sulfameter (5-methoxysulfadiazine), this was done by studying the kinetics of their desolvation reaction both isothermally and nonisothermally. Calculated kinetic parameters were compared and related to the crystal structure of these solvates. A relationship was established between desolvation kinetic parameters (e.g., activation energy) and the solvent size. The solid-state reaction models selected also corresponded to the single crystal structure of the sulfameter-solvate system.
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Title: APPLICATION OF SOLID-STATE KINETICS TO ...
Publisher: VDM Verlag Dr. Müller
Publication Date: 2013
Binding: Taschenbuch
Condition: Neu
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The book presents an overview of the solid-statekinetic literature including methodologies used,mathematical derivations and pharmaceuticalapplications. The book investigates the relationship betweencalculation methods and artifactual results observedin solid-state kinetics. A new approach is proposedfor evaluating solid-state kinetic data, thisapproach combines modelistic and model-free methodsin a complimentary manner to achieve consistentkinetic results.Experimental data focused on studying the solid-statestability of several structurallyrelated solvates of sulfameter(5 methoxysulfadiazine), this was done by studyingthe kinetics of their desolvation reaction bothisothermally and nonisothermally. Calculated kineticparameters were compared and related to the crystalstructure of these solvates. A relationship wasestablished between desolvation kinetic parameters(e.g., activation energy) and the solvent size. Thesolid-state reaction models selected alsocorresponded to the single crystal structure of thesulfameter-solvate system. Seller Inventory # 9783639091144
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APPLICATION OF SOLID-STATE KINETICS TO DESOLVATIONREACTIONS
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ISBN 13: 9783639091144
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