AIDS and Pancreas in the HAART Era: A Cross Sectional Study

Language: English

Published by LAP LAMBERT Academic Publishing, 2014

3659613827 / 9783659613821

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - This study aims identify the main morphological patterns of pancreas in AIDS patients using Higly Active Antiretorviral Therapy (HAART). We compared adults who died of AIDS using HAART and underwent autopsy with 109 AIDS patients without HAART therapy. The HAART group presented lighter pancreas abnormalities than no HAART users. In the HAART group, histology shows: reduction of zymogen granules in the acinar cells (ZG), lower dysplasia-like and higher pancreatic acinar atrophy. The exocrine pancreas in treated patients was distinguished by the high level of atrophy, sharp reduction of zymogen granules and high level of apoptosis, reflecting degeneration and lower level of proteincaloric malnutrition. The islets of Langerhans in HAART group were increased in number and volume and with high level of nuclear dysplasia. The antiviral therapy and a longer survival resulted in a higher atrophy and reduction of enzymes, increasing the apoptosis and generated important changes in the pancreatic islets, probably resulting in clinical/laboratory repercussion. We found no evidence of pancreatic histological lesions secondary to antiretroviral therapy. …

Seller Inventory # 9783659613821

Title
AIDS and Pancreas in the HAART Era: A Cross Sectional Study
Author
Ethel Chehter
Publisher
LAP LAMBERT Academic Publishing
Publication year
2014
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659613827
ISBN 13
9783659613821
Item weight
131 grams
Dimensions
220x150x6 mm

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