Roles of Mitophagy in Cancer Regulation - Hardcover

Hardcover

ISBN 13: 9798369338360

Publisher: Igi Global Scientific Publishing, 2025

Synopsis

Mitogaphy is a selective autophagic degradation of mitochondria, playing a crucial role in maintaining cellular homeostasis by eliminating damaged or dysfunctional mitochondria. Relating to cancer, mitophagy influences tumorigenesis, progression, and therapeutic response in complex and contradictory ways. By regulating mitochondrial quality control, energy metabolism, and apoptotic signaling, mitophagy contributes to the delicate balance between cell survival and death. This process can support cancer cell survival under stress conditions such as hypoxia and nutrient deprivation, yet it can suppress tumor development by limiting oxidative stress and genome instability. Understanding the multifaceted roles of mitophagy in cancer regulation is essential for developing targeted therapeutic strategies and improving clinical outcomes. Roles of Mitophagy in Cancer Regulation explores how mitophagy influences cell differentiation and its central role in cellular activities. It examines how mitophagy is regulated in cancer, the removal of damaged mitochondria through autophagy, and the maintenance of proper cellular functions. Covering topics such as cellular biology, DNA, and mitochondrial science, this book is an excellent resource for engineers, medical professionals, academicians, scientists, and researchers.

About this title

About the Author

Ashok Kumar Pandurangan is an Associate Professor working (August 2017 onwards) in the School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India. Recently, he has been listed three times as one of the Top 2% of Scientists (2020-2022) in the field of Oncology and Toxicology by Stanford University, USA. He completed his Ph.D. in the Department of Biochemistry, University of Madras, Chennai, India, from 2006-2011. Later, he worked as a postdoctoral fellow in the Centre for Cancer Research, Children's Hospital Oakland Research Institute (California, USA), in the field of S1PLyase deficiency in colitis-associated cancer. Then he worked as a postdoctoral fellow in the Department of Nutrition and Dietetics, Universiti of Putra Malaysia (UPM), Serdang, Malaysia. Further, he worked as a Visiting Research Fellow in the Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia. He published over 67 research and reviewed articles in peer-reviewed journals 5 books, and 27 book chapters. He received a Teachers Associateship Research Excellence (TARE) grant from SERB, India, in 2018 and several grants in Malaysia.

Edition details

• Publisher: Igi Global Scientific Publishing
• Publication date: 2025
• Language: English
• ISBN 13: 9798369338360
• Binding: Hardcover
• Number of pages: 375
• Editor: Pandurangan Ashok Kumar