Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and COVID-19 - Softcover

Byun, Wan Gi

Softcover

ISBN 10: 9811978158 ISBN 13: 9789811978159

Publisher: Springer, 2022

Synopsis

This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19.

Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

Edition details

• Publisher: Springer
• Publication date: 2022
• Language: English
• ISBN 10: 9811978158
• ISBN 13: 9789811978159
• Binding: Paperback
• Number of pages: 162