Advancing Methods for Biomolecular Crystallography (NATO Science for Peace and Security Series A: Chemistry and Biology) - Hardcover

Hardcover

ISBN 10: 9400762313 ISBN 13: 9789400762312

Publisher: Springer, 2013

Synopsis

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web.  Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis.  These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome.  Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.

About this title

From the Back Cover

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.

Edition details

• Publisher: Springer
• Publication date: 2013
• Language: English
• ISBN 10: 9400762313
• ISBN 13: 9789400762312
• Binding: Hardcover
• Number of pages: 375
• Editor: Read Randy, Urzhumtsev Alexandre G., Lunin Vladimir Y.