Items related to In Silico and in Vitro Aldose Reductase Inhibition...

In Silico and in Vitro Aldose Reductase Inhibition of Flavonoids: IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITORY ACTIVITY OF SOME SYNTHESIZED FLAVONOID DERIVATIVES - Softcover

Vijayabaskaran, M; Kape Meyar, E; Madeswaran, A

 
9786209863264: In Silico and in Vitro Aldose Reductase Inhibition of Flavonoids: IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITORY ACTIVITY OF SOME SYNTHESIZED FLAVONOID DERIVATIVES
Softcover
ISBN 10: 6209863264 ISBN 13: 9786209863264
Publisher: LAP Lambert Academic Publishing, 2026

Synopsis

Cataracts are one of the primary causes of visual impairment in diabetics. Patients with diabetes mellitus are said to be five times more likely to acquire cataracts, particularly if they begin the condition early. Flavonoids are bioactive secondary metabolites of plants that belong to a large family of low molecular weight compounds and have a polyphenolic structure. This comprehensive book explores the therapeutic potential of novel flavonoid derivatives in combating diabetic cataractogenesis. Utilizing a multi-disciplinary approach, the research integrates in silico molecular docking to identify high-affinity aldose reductase inhibitors (ARIs) with traditional chemical synthesis and characterization techniques. The core of the investigation lies in a rigorous in vitro evaluation using isolated goat lenses, demonstrating how these specialized compounds retard lens opacification and mitigate oxidative stress. This book provides a critical scaffold for the development of non-surgical, plant-derived pharmacological interventions for vision preservation.

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Publisher
LAP Lambert Academic Publishing
Publication date
2026
Language
English
ISBN 10 
6209863264
ISBN 13 
9786209863264
Binding
Paperback
Number of pages
96