Items related to Yes Associated Protein (YAP) as a Prognostic Predictor...

Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer: YAP in Oral Precancer and Oral Squamous Cell Carcinoma - Softcover

Nandhakumar, Indumathi; Thayalan, Dineshkumar

 
9786209363528: Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer: YAP in Oral Precancer and Oral Squamous Cell Carcinoma
Softcover
ISBN 10: 6209363520 ISBN 13: 9786209363528
Publisher: LAP LAMBERT Academic Publishing, 2025

Synopsis

This study explores the expression of Yes-associated protein (YAP), a key effector of the Hippo pathway, across the spectrum of oral carcinogenesis. Using immunohistochemistry on ethically sourced samples of normal oral mucosa, leukoplakia, and oral squamous cell carcinoma (OSCC), we observed a clear, progressive rise in YAP staining from healthy tissue to dysplasia and finally to OSCC. Dysplastic lesions showed stepwise increases in YAP intensity correlating with severity, while OSCC displayed the highest expression. Both nuclear and cytoplasmic staining were evident, with nuclear positivity (>10%) highlighting YAP’s active transcriptional role in promoting cell growth and malignant transformation. These findings suggest that YAP is a significant biomarker and potential driver of oral cancer progression.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2025
Language
English
ISBN 10 
6209363520
ISBN 13 
9786209363528
Binding
Paperback
Number of pages
84