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Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis: Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis - Softcover

El-Banna, Mona

 
9786208429102: Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis: Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis
Softcover
ISBN 10: 6208429102 ISBN 13: 9786208429102
Publisher: LAP LAMBERT Academic Publishing, 2025

Synopsis

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, leading to increased fracture risk. Multiple factors contribute to its pathogenesis, including hormonal deficiencies (estrogen, testosterone, and growth hormone), metabolic imbalances, chronic inflammation, glucocorticoid therapy, and lifestyle-related influences. Glucocorticoids (GCs) play a significant role in osteoporosis by inhibiting osteoblast differentiation, promoting osteoclast activity via the RANKL-OPG pathway, impairing calcium absorption, and disrupting vitamin D metabolism. Additionally, inflammatory cytokines, growth factors, and prostanoids influence bone remodeling, further exacerbating bone loss. Management strategies include lifestyle modifications, adequate calcium and vitamin D intake, pharmacologic interventions (bisphosphonates, SERMs, PTH analogs, and monoclonal antibodies), and hormone replacement therapy where applicable. Early detection and intervention are essential to prevent fractures and maintain skeletal health.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2025
Language
English
ISBN 10 
6208429102
ISBN 13 
9786208429102
Binding
Paperback
Number of pages
88